The CDC Division of Notifiable Disease and Healthcare Information (DNDHI) engaged PHII to conduct an analysis (summarization of system capabilities and core competencies) of selected commercial off-the-shelf (COTS) Electronic Disease Surveillance System (EDSS) vendors, and to distribute the findings to local and state health departments. The purpose of this analysis is to help state and local health departments explore the potential of available surveillance systems to meet their needs, framing the landscape of the EDSS world so that they can make informed surveillance IT decisions.