Increasing demand to provide integrated data requires public health programs and healthcare provider organizations to adopt a strategic approach to uniquely identifying individuals whose data are held in disparate data sources or information systems. Matching person-specific data from multiple sources to produce linked data sets or merged records is fundamental to the quality of data and the integrity of the information being provided by the integrated systems. The concepts, examples, and tools in The Unique Records Portfolio are intended to help public health agencies and healthcare organizations address the deduplication challenge, specifically articulating the challenges and solutions to developing deduplication strategies, and describing the implications that various approaches have on data use.