The National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention (CDC) has partnered with the Public Health Informatics Institute (PHII) to develop a self-assessment activity designed to increase the EHDI program’s capability to exchange electronic health information with clinical electronic health record systems (EHRs). This self-assessment tool can help facilitate strategic planning in state/territorial EHDI programs. It provides a forum for EHDI coordinators to discuss their information system needs with their partners in the agency’s leadership, information technology or eHealth units. Participating in this self-assessment activity will give EHDI coordinators a clearer understanding of success factors and the agency’s current capabilities. It also provides guidance on what characteristics the program and agency can adopt for greater interoperability with clinical partners.