Public Health Informatics 2023: Alternative Scenarios was created to consider the range of forces, challenges, and opportunities shaping public health informatics in the United States so that leaders and practitioners can make strategic decisions that more effectively take the future into account. Public health informatics, like healthcare and public health, faces major uncertainties and challenges, but may also take advantage of major opportunities. These 2023 scenarios are part of the Public Health Informatics Institute project “Using Public Health Information in the eHealth Decade,” funded by the Robert Wood Johnson Foundation. The purpose of the project is to develop a better understanding of the key forces shaping the future of public health informatics in the United States, and to help public health practitioners create strategies that ensure the quality and resilience of public health informatics in light of emerging challenges, opportunities, and uncertainties.