The importance of functional health information systems in achieving improved health outcomes continues to grow, yet the reality in most developing countries is that the systems and health information technologies which support them are often poorly designed and unable to work together as a sustainable and scalable system. Donors and countries alike recognize the need to establish architecture and reusable tools for more systematically building global health information systems. This project was funded to address that need and had two main objectives; (1) develop a general methodology for determining and documenting health information system user requirements and (2) apply this methodology to produce requirements in supply chain as one of the core functional domains of a national health system.